Pepo Peso was born in 1918 in Bitola, as one of the three children of Malka and Jakov Peso. He comes from a poor Jewish family, and due to the circumstances in which his family lived, he was unable to go to school and was forced to study glassmaking in order to contribute to his family's survival.

From an early age, Pepo belonged to the circle of progressive youth in Bitola. He was a member of the Union of Communist Youth of Yugoslavia and was one of the first Jews from Bitola to join the resistance movement.

The leaders of the Bitola resistance movement, led by Stiv Naumov, begun taking steps to establish combat groups around Bitola. In April 1942, near the village of Lavci, on Baba Mountain, Pepo Peso took part in the formation of the first partisan detachment (a military formation with partisans from Bitola) named "Pelister". The detachment existed for a short time, it was poorly armed and without military experience, and after clashes with the occupying army, which was well supplied and with many collaborators, the detachment was surrounded and broken. Pepo Peso, one of the first partisan Jews from Bitola, also took part in the clash between the partisan detachment "Pelister" and the Bulgarian occupying army, where he was killed.